The chemist penned and signed this note asking Mr. Potterin to speak to him later Autograph Note signed: "L.P.", in black ink. One page. 2¾x1¼. To "Mr. Potterin - Eugene". In French, translated in full: "Speak to me about him after/the arrival of Mr. Lapetair, the injector, etc." Louis Pasteur (1822-1895) was a chemist and biologist who is considered one of a handful of the most important pioneers of microbiology. His body of work directly led to the development of vaccinations to protect humans from deadly diseases, the invalidation of the spontaneous generation theory of life, and the invention of pasteurization. Pasteurization is the process of heating dairy products to eliminate microbial organisms that can spread disease. Germ theory was already rapidly growing support, but Pasteur conducted controlled experiments from 1860-1864 that investigated germs, disease, and potential causality. These experiments put to rest any further serious opposition to the theory. While Pasteur's influence on microbiology and chemistry stretch far into the sciences, his notoriety today is primarily due to the namesake process of pasteurization used on virtually all dairy products sold in stores.

The man who pioneered the concept of the space shuttle writes about space travel. Autograph Manuscript signed: "By Dr. Wernher von Braun" in title, 1p, 8¼ x 10½ ruled sheet. Manuscript page, which is written in pencil, is part of a longer manuscript ("1" written by von Braun at upper margin). Headed: "Space Travel/by Dr. Wernher von Braun/Chief, Guided Missile Development Division//Redstone Arsenal, Huntsville, Ala." In full: "There are few dreams of the future which have woven so fascinating a web around human fantasy as flight through space. Since the first, epoch-making experiments of the great American pioneer of rocketry, Robert H. Goddard; since the days when Hermann Oberth, the German, and the Russian Constantin E. Ziolkovsky published their startling writings on rocket propulsion, a veritable spate of literature has overwhelmed the public. This has covered the entire field ranging from serious, scientific dissertations to comic strips. Thus, the intelligent layman outsider who is at tempting to sift the actual promises of space flight from idle conjecture frequently finds himself more confused than before he began to [word crossed out] study space flight literature.…"

The businessman signed this letter that's beautifully framed with an image of him! Typed Letter Signed: "F. O. Stanley" on an 8½x11 sheet of paper (8¼x10 visible). One page. Dated October 9, 1911. Message in Part: "I am enclosing checks amounting to $3000. In reference to lease of the State land you mention, I have no objection to having it transferred to you, provided it is agreeable to Mr. Young, and I am writing him in reference to the same". Freelan O. Stanley (1849-1940) and his brother Francis E. Stanley became businessmen who developed the Stanley Motor Carriage Company, eventually building the Stanley Steamer. Their steam-powered automobiles grew extremely popular, although it was eventually superseded by the Model T. Steam engine vehicles gradually became obsolete technologically. After Stanley was diagnosed with a life-threatening case of tuberculosis in 1903, Stanley resolved to get some fresh air. Until his death in 1940, Stanley for the most part resided in Estes Park, Colorado. Through his investment in the fledgling town, Estes Park grew significantly.

The famous inventor penned a section of answers on this questionnaire! Printed Questionnaire filled out by an assistant who has signed: "Thomas A. Edison" at the conclusion, but with 11 words in Edison's hand, 1p, 7¾x10½. J.K. Macomber, Professor of Physics at the Physical Laboratory Agricultural College in Ames, Iowa, sent Edison and other authorities in the field, a printed questionnaire, dated September 27, 1879. Macomber message, in part: "The people of the Western States have been imposed upon by lightning-rod peddlers more, perhaps, than by any other class of swindlers. Among other rods being sold in Iowa is one known as the 'Chambers' rod, widely has been patented by the 'Chambers' National Lightning Protection Company,' of Cincinnati, Ohio. Briefly, this system consists on an Iron rod running along the ridge of the building with points at each end projecting upward…Many public buildings in thus State have been furnished with these rods…I beg leave to submit the following interrogations." Macomber lists seven questions for Edison to answer. Edison dictated his answers to an assistant who handwrote his replies in a hand resembling Edison's.

Extraordinary photograph capturing the two innovators together. Rare Photograph signed: "Henry Ford" and "Harry Ferguson". Sepia, 13¾ x 11 overall, image 11 x 8 (one surface). HARRY FERGUSON, a manufacturer of tractors in England and Ireland, developed the Ferguson tractor, a scale model of which is shown on the table in this photograph. His system of tractor-implement integration utilized a hitch, the linkages, and controls of which made the tractor and implement work as a single unit operated almost entirely from the seat of the tractor. Seeking an American market for his product, Ferguson entered into an agreement with HENRY FORD and the Ford Motor Company. Ford, who had formed Ford Motor Company in 1903 and was noted for introducing the successful assembly-line method of production, was to manufacture and market the Ferguson tractor in the U.S. The company commenced making the tractors in 1938, but the agreement was terminated after WWII. Ferguson then began manufacturing his own equipment in Great Britain and the U.S. Portions of 3 middle letters of Ferguson's signature on dark portion (adequate contrast). Minor surface blemishes at blank margins. Fine condition. Frame has minor surface ships and wearing at corners.

The famed mathematician sends a dinner invitation. Third Person ANS: "Mr. Babbage", 1p, 3½ x 3¾. Dorset St., (no year) May 23. In full: "Mr. Babbage will have the honor of dining with Mr & Mrs Strutt on Saturday the 11th June". Charles Babbage (1791-1871) is known as the "Father of Computing" for his ideas about building an analytical engine, the predecessor of the digital computer. He proposed operations research that involved the idea of using machines to perform routine mathematical operations, eliminating errors in human calculation. By 1825, he had developed a machine that was capable of calculating up to 20 decimals. Plans formulated by Babbage in the mid-1830s became the basis for the computers that emerged in the 1940s and 1950s. Lightly stained at upper right blank corner. Fine condition. Framed to an overall size of 27½ x 16¼. Frame exhibits wearing at corners.

Fulton signed this document - buying 32 lots of land in the town of Jersey, New Jersey for $1,000 - in 1809. He signed it the same year that he filed his first patent for improvements in navigation by steam and one year after marrying his wife Harriet Livingston. Pieces by Fulton are rare in any form, and legal documents, like this, are doubly so. Accompanied by an unsigned engraving of Fulton based on an Alonzo Chappel portrait. Manuscript document signed "Robert Fulton". 3 pages plus docket, 7½x12¼, 2 sheets front and verso, with embossed Jersey Company seal and 1-inch square paper seal on page 3 by signatures. Nov. 3, 1809. This document was signed between Fulton and the president of the Jersey Company. Fulton agreed to buy a block of land containing 32 lots in the town of Jersey in Bergen County, New Jersey for $1,000. Fulton signed this document one year after marrying Harriet Livingston, his partner's niece, and the same year that he filed his first patent for improvements in navigation by steam. Fulton is scarce in any form and this is a fine example suitable for framing and display. Lightly toned, stained, soiled and creased. Random ink stains. Edges are torn. Pinholes in both sheets. Corners are rounded Folded thrice and unfolded. Worn, torn, toned and with pinholes along folds.

The founder of the Chrysler car manufacturer signed this printed pencil sketch in ink on January 27, 1934 Printed Art Signed in Ink: "W. P. Chrysler 1/27/34". Original pencil sketch was drawn by M. H. Herrin; this is a printed copy of that sketch. Sketch is 5¼x8¼ on a sheet, 7¾x10½ of which is visible. Features plaque. Walter P. Chrysler Sr. (1875-1940) began his professional career with an apprenticeship as a railroad mechanic. He got his start in the automotive industry in 1911 with Buick in Flint, Michigan. By the end of the decade he was one of the wealthiest men in the United States due to his skills at mechanical engineering and cutting costs. After gaining control of the Maxwell Motor Company, he formed Chrysler Corporation in 1925 and later bought Dodge. He built New York City's Chrysler Building in 1960. Frame lightly chipped in one spot towards bottom left corner. Image lightly toned. Otherwise, fine condition. Framed to an overall size of 19x29.

. Black-bordered ALS: "Lister", 1p, 4x6. Portland Place, London, 1899 September 14. To Dr. John D. Scott. In full: "I thank you for the copy you have kindly sent me of your eloquent address in which you properly vindicate the honour of our noble profession. I thank you also for your exceedingly generous reference to my own work." Joseph Lister, created 1st Baron Lister of Lime Regis in 1897, was the founder of antiseptic surgery. He introduced carbolic acid as an antiseptic in 1865 and in 1877, demonstrated conclusively that his method of antisepsis reduced danger to life from surgery. Fine condition. Framed to an overall size of29x22.

Rare manuscript letter written from his estate in England to Inslee Hopper, his successor as head of the Singer Manufacturing Co. in New York. Hopper has added his receipt acknowledgement in purple ink! Manuscript Letter signed: "I M Singer", 1p, 5x8. Paignion, South Devon, England, 1873 July 8. To The Director of the Singer Manufacturing Co., New York. In full: "On receipt of this letter, please send me sight Bill of Exchange for Five thousand pounds (£5000) but should Gold and Exchange exceed 125 you may wait until you are able to buy at that price. I have telegraphed to Mr. Hawley to come out, and write to you as I expect he will sail before this letter arrives." Ink note receipt acknowledgement by Singer President Inslee Hopper: "July 23 73". Singer received his first patent for a commercial sewing machine in 1851. Three years later, he introduced a domestic model that made him one of the wealthiest Americans of the century. In late 1857, Singer opened the world's first mass production facility for something other than firearms in New York. I.M. Singer & Company was soon able to cut production costs to a little more than $10.00 per machine. Singer sold his new machines for 50% less than his first, yet had increased his profit margin to 530% per machine.

Inscribed and signed photo of the film pioneering showing off photographs of the Lumière brothers and some early pieces of movie equipment. Photograph inscribed and signed: "To Mr. Marx Reimers/From/Francis Doublier/1894./Motion Picture Pioneer/April 20th 1941/Fort Lee, N.J." B/w, 7¼ x 9½. Doublier, who is surrounded by relics from the early days of motion pictures, has also initialed: "F.D." under a description of several pieces of equipment. In full: "Camera, printer,/projector used/in 1895 to 1900". He has also identified two photographs displayed around him: "Louis Lumière" and "Auguste and Louis Lumière". FRANCIS DOUBLIER (1878-1948), the first to see moving pictures projected onto a wall, signed and dated this photograph while Vice President of Major Film Laboratories, Inc. of New York. His photographic career began in 1894, when the 16-year-old became associated with brothers AUGUSTE MARIE NICOLAS LUMIÈRE (1862-1954) and LOUIS JEAN LUMIÈRE (1864-1948) and their experimentation with motion picture photography.

The two sign a 3-page, handwritten 1863 letter to their son Willy, away at school Autograph letter signed: "Yr Affectionate Father/Saml F.B. Morse" and "Your loving mother/S.E. Morse", 1 page, 4½x7½. 5 West 32nd Street, 1863 November 22. To their son Willy. Samuel F. B. Morse married his second wife, Sarah Elizabeth Griswold, in 1848. In a three-page letter, Mrs. Morse writes about family affairs, about his pet "Spottie is full of mischief. He tears many things that comes in his way." She tells him she is "going to have somethings on Christmas" wanting to know if he has "enough handkerchiefs…." Beneath his wife's signature, Morse writes, in part: "I add a few lines to your dear mother's letter. She says the truth when she says she thinks of you every day. Both you & dear Arthur are constantly in our thoughts…You must do all you can to please Mrs. Charles, Mrs. Fay and the other teachers and be diligent in your Studies…." Samuel Finley Breese Morse (1791-1872) was an American painter and inventor. While attending Yale College Morse painted for a living and later studied art in Europe.